Cancer

  • Success stories June 21, 2018
    Success storiesSuccess stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-yAnalyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
    Ulrike Harjes
  • Tumours trigger systemic disruption June 20, 2018
    Tumours trigger systemic disruptionTumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).
    Sarah Seton-Rogers
  • Falling short to compete June 18, 2018
    Falling short to competeFalling short to compete, Published online: 19 June 2018; doi:10.1038/s41568-018-0036-1Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing. […]
    Paulina Strzyz
  • Metabolizing microbes in control June 17, 2018
    Metabolizing microbes in controlMetabolizing microbes in control, Published online: 18 June 2018; doi:10.1038/s41568-018-0035-2The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.
    Anna Dart
  • Targeting ATR in cancer June 12, 2018
    Targeting ATR in cancerTargeting ATR in cancer, Published online: 13 June 2018; doi:10.1038/s41568-018-0034-3This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patien […]
    Emilio Lecona
  • Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals June 10, 2018
    Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammalsInsights on cancer resistance in vertebrates: reptiles as a parallel system to mammals, Published online: 11 June 2018; doi:10.1038/s41568-018-0033-4Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals
    Ylenia Chiari
  • Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow June 10, 2018
    Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flowEco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, Published online: 11 June 2018; doi:10.1038/s41568-018-0030-7This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. I […]
    Robert J. Gillies
  • It’s all Greek to me June 5, 2018
    It’s all Greek to meIt’s all Greek to me, Published online: 06 June 2018; doi:10.1038/s41568-018-0032-5Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.
    Anna Dart

  • Success stories June 21, 2018
    Success storiesSuccess stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-yAnalyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
    Ulrike Harjes
  • Tumours trigger systemic disruption June 20, 2018
    Tumours trigger systemic disruptionTumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).
    Sarah Seton-Rogers
  • Falling short to compete June 18, 2018
    Falling short to competeFalling short to compete, Published online: 19 June 2018; doi:10.1038/s41568-018-0036-1Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing. […]
    Paulina Strzyz
  • Metabolizing microbes in control June 17, 2018
    Metabolizing microbes in controlMetabolizing microbes in control, Published online: 18 June 2018; doi:10.1038/s41568-018-0035-2The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.
    Anna Dart
  • Targeting ATR in cancer June 12, 2018
    Targeting ATR in cancerTargeting ATR in cancer, Published online: 13 June 2018; doi:10.1038/s41568-018-0034-3This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patien […]
    Emilio Lecona
  • Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals June 10, 2018
    Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammalsInsights on cancer resistance in vertebrates: reptiles as a parallel system to mammals, Published online: 11 June 2018; doi:10.1038/s41568-018-0033-4Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals
    Ylenia Chiari
  • Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow June 10, 2018
    Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flowEco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, Published online: 11 June 2018; doi:10.1038/s41568-018-0030-7This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. I […]
    Robert J. Gillies
  • It’s all Greek to me June 5, 2018
    It’s all Greek to meIt’s all Greek to me, Published online: 06 June 2018; doi:10.1038/s41568-018-0032-5Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.
    Anna Dart

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