Drug Discovery

  • Genome editing to 're-write' wrongs June 21, 2018
    Genome editing to 're-write' wrongsGenome editing to 're-write' wrongs, Published online: 22 June 2018; doi:10.1038/nrd.2018.91The NIH has launched the Somatic Cell Genome Editing (SCGE) programme to accelerate the development of safer and more effective genome-editing therapeutics.
    Mary Ellen Perry
  • Stroke: Opening the therapeutic window June 14, 2018
    Stroke: Opening the therapeutic windowStroke: Opening the therapeutic window, Published online: 15 June 2018; doi:10.1038/nrd.2018.98Stroke: Opening the therapeutic window
    Sarah Crunkhorn
  • Cancer: Re-educating tumour-associated macrophages with nanoparticles June 14, 2018
    Cancer: Re-educating tumour-associated macrophages with nanoparticlesCancer: Re-educating tumour-associated macrophages with nanoparticles, Published online: 15 June 2018; doi:10.1038/nrd.2018.102Cancer: Re-educating tumour-associated macrophages with nanoparticles
    Megan Cully
  • The promise and challenges of immune agonist antibody development in cancer June 14, 2018
    The promise and challenges of immune agonist antibody development in cancerThe promise and challenges of immune agonist antibody development in cancer, Published online: 15 June 2018; doi:10.1038/nrd.2018.75Co-stimulatory receptors mediate the anticancer immune response. This Review discusses the current efforts in targeting co-stimulatory receptors with ago […]
    Patrick A. Mayes
  • Infectious diseases: The painful path to avoiding the immune system June 14, 2018
    Infectious diseases: The painful path to avoiding the immune systemInfectious diseases: The painful path to avoiding the immune system, Published online: 15 June 2018; doi:10.1038/nrd.2018.100Infectious diseases: The painful path to avoiding the immune system
    M. Teresa Villanueva
  • The market for oral anticoagulants June 14, 2018
    The market for oral anticoagulantsThe market for oral anticoagulants, Published online: 15 June 2018; doi:10.1038/nrd.2018.89This article discusses the market for oral anticoagulants, and how therapies in development and antidotes to existing drugs could affect the therapeutic landscape.
    Stephen Bielecki
  • Overcoming the legal and regulatory barriers to drug repurposing June 7, 2018
    Overcoming the legal and regulatory barriers to drug repurposingOvercoming the legal and regulatory barriers to drug repurposing, Published online: 08 June 2018; doi:10.1038/nrd.2018.92Drug repurposing has been proposed as a strategy to develop new therapies that has fewer risks, lower costs and shorter timelines than developing completely new drugs. However […]
    Alasdair Breckenridge
  • Cryo-EM in drug discovery: achievements, limitations and prospects June 7, 2018
    Cryo-EM in drug discovery: achievements, limitations and prospectsCryo-EM in drug discovery: achievements, limitations and prospects, Published online: 08 June 2018; doi:10.1038/nrd.2018.77Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules an […]
    Jean-Paul Renaud

  • Genome editing to 're-write' wrongs June 21, 2018
    Genome editing to 're-write' wrongsGenome editing to 're-write' wrongs, Published online: 22 June 2018; doi:10.1038/nrd.2018.91The NIH has launched the Somatic Cell Genome Editing (SCGE) programme to accelerate the development of safer and more effective genome-editing therapeutics.
    Mary Ellen Perry
  • Stroke: Opening the therapeutic window June 14, 2018
    Stroke: Opening the therapeutic windowStroke: Opening the therapeutic window, Published online: 15 June 2018; doi:10.1038/nrd.2018.98Stroke: Opening the therapeutic window
    Sarah Crunkhorn
  • Cancer: Re-educating tumour-associated macrophages with nanoparticles June 14, 2018
    Cancer: Re-educating tumour-associated macrophages with nanoparticlesCancer: Re-educating tumour-associated macrophages with nanoparticles, Published online: 15 June 2018; doi:10.1038/nrd.2018.102Cancer: Re-educating tumour-associated macrophages with nanoparticles
    Megan Cully
  • The promise and challenges of immune agonist antibody development in cancer June 14, 2018
    The promise and challenges of immune agonist antibody development in cancerThe promise and challenges of immune agonist antibody development in cancer, Published online: 15 June 2018; doi:10.1038/nrd.2018.75Co-stimulatory receptors mediate the anticancer immune response. This Review discusses the current efforts in targeting co-stimulatory receptors with ago […]
    Patrick A. Mayes
  • Infectious diseases: The painful path to avoiding the immune system June 14, 2018
    Infectious diseases: The painful path to avoiding the immune systemInfectious diseases: The painful path to avoiding the immune system, Published online: 15 June 2018; doi:10.1038/nrd.2018.100Infectious diseases: The painful path to avoiding the immune system
    M. Teresa Villanueva
  • The market for oral anticoagulants June 14, 2018
    The market for oral anticoagulantsThe market for oral anticoagulants, Published online: 15 June 2018; doi:10.1038/nrd.2018.89This article discusses the market for oral anticoagulants, and how therapies in development and antidotes to existing drugs could affect the therapeutic landscape.
    Stephen Bielecki
  • Overcoming the legal and regulatory barriers to drug repurposing June 7, 2018
    Overcoming the legal and regulatory barriers to drug repurposingOvercoming the legal and regulatory barriers to drug repurposing, Published online: 08 June 2018; doi:10.1038/nrd.2018.92Drug repurposing has been proposed as a strategy to develop new therapies that has fewer risks, lower costs and shorter timelines than developing completely new drugs. However […]
    Alasdair Breckenridge
  • Cryo-EM in drug discovery: achievements, limitations and prospects June 7, 2018
    Cryo-EM in drug discovery: achievements, limitations and prospectsCryo-EM in drug discovery: achievements, limitations and prospects, Published online: 08 June 2018; doi:10.1038/nrd.2018.77Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules an […]
    Jean-Paul Renaud

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