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  • Analysis of shared heritability in common disorders of the brain June 21, 2018
    Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 […]
    The Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., Malik, R., Patsopoulos, N. A., Ripke, S., Wei, Z., Yu, D., Lee, P. H., Turley, P., Grenier-Boley, B., Chouraki, V., Kamatani, Y., Berr, C., Letenneur, L., Hannequin, D., Amouyel, P., Boland, A., Deleuze, J.-F., Duron, E., Vardarajan, B. N., Reitz, C., Goate, A. M., Huentelman, M. J., Kamboh, M. I., Larson, E. B., Rogaeva, E., St George-Hyslop, P., Hakonarson, H., Kukull, W. A., Farrer, L. A., Barnes, L. L., Beach, T. G., Demirci, F. Y., Head, E., Hulette, C. M., Jicha, G. A., Kauwe, J. S. K., Kaye, J. A., Leverenz, J. B., Levey, A. I., Lieberman, A. P., Pankratz, V. S., Poon, W. W., Quinn, J. F., Saykin, A. J., Schneider, L. S., Smith, A. G., Sonnen, J. A., Stern, R. A., Van Deerlin, V. M., Van Eldik, L. J., Harold, D., Russo, G., Rubinsztein, D. C., Bayer, A., Tsolaki, M., Proitsi, P., Fox, N. C., Hampel, H., Owen, M. J., Mead, S., Passmore, P., Morgan, K., Nöthen, M. M., Rossor, M., Lupton, M. K., Hoffmann, P., Kornhuber, J., Lawlor, B., McQuillin, A., Al-Chalabi, A., Bis, J. C., Ruiz, A., Boada, M., Seshadri, S., Beiser, A., Rice, K., van der Lee, S. J., De Jager, P. L., Geschwind, D. H., Riemenschneider, M., Riedel-Heller, S., Rotter, J. I., Ransmayr, G., Hyman, B. T., Cruchaga, C., Alegret, M., Winsvold, B., Palta, P., Farh, K.-H., Cuenca-Leon, E., Furlotte, N., Kurth, T., Ligthart, L., Terwindt, G. M., Freilinger, T., Ran, C., Gordon, S. D., Borck, G., Adams, H. H. H., Lehtimäki, T., Wedenoja, J., Buring, J. E., Schürks, M., Hrafnsdottir, M., Hottenga, J.-J., Penninx, B., Artto, V., Kaunisto, M., Vepsäläinen, S., Martin, N. G., Montgomery, G. W., Kurki, M. I., Hämäläinen, E., Huang, H., Huang, J., Sandor, C., Webber, C., Muller-Myhsok, B., Schreiber, S., Salomaa, V., Loehrer, E., Göbel, H., Macaya, A., Pozo-Rosich, P., Hansen, T., Werge, T., Kaprio, J., Metspalu, A., Kubisch, C., Ferrari, M. D., Belin, A. C., van den Maagdenberg, A. M. J. M., Zwart, J.-A., Boomsma, D., Eriksson, N., Olesen, J., Chasman, D. I., Nyholt, D. R., Avbersek, A., Baum, L., Berkovic, S., Bradfield, J., Buono, R., Catarino, C. B., Cossette, P., De Jonghe, P., Depondt, C., Dlugos, D., Ferraro, T. N., French, J., Hjalgrim, H., Jamnadas-Khoda, J., Kälviäinen, R., Kunz, W. S., Lerche, H., Leu, C., Lindhout, D., Lo, W., Lowenstein, D., McCormack, M., Moller, R. S., Molloy, A., Ng, P.-W., Oliver, K., Privitera, M., Radtke, R., Ruppert, A.-K., Sander, T., Schachter, S., Schankin, C., Scheffer, I., Schoch, S., Sisodiya, S. M., Smith, P., Sperling, M., Striano, P., Surges, R., Thomas, G. N., Visscher, F., Whelan, C. D., Zara, F., Heinzen, E. L., Marson, A., Becker, F., Stroink, H., Zimprich, F., Gasser, T., Gibbs, R., Heutink, P., Martinez, M., Morris, H. R., Sharma, M., Ryten, M., Mok, K. Y., Pulit, S., Bevan, S., Holliday, E., Attia, J., Battey, T., Boncoraglio, G., Thijs, V., Chen, W.-M., Mitchell, B., Rothwell, P., Sharma, P., Sudlow, C., Vicente, A., Markus, H., Kourkoulis, C., Pera, J., Raffeld, M., Silliman, S., Boraska Perica, V., Thornton, L. M., Huckins, L. M., William Rayner, N., Lewis, C. M., Gratacos, M., Rybakowski, F., Keski-Rahkonen, A., Raevuori, A., Hudson, J. I., Reichborn-Kjennerud, T., Monteleone, P., Karwautz, A., Mannik, K., Baker, J. H., OToole, J. K., Trace, S. E., Davis, O. S. P., Helder, S. G., Ehrlich, S., Herpertz-Dahlmann, B., Danner, U. N., van Elburg, A. A., Clementi, M., Forzan, M., Docampo, E., Lissowska, J., Hauser, J., Tortorella, A., Maj, M., Gonidakis, F., Tziouvas, K., Papezova, H., Yilmaz, Z., Wagner, G., Cohen-Woods, S., Herms, S., Julia, A., Rabionet, R., Dick, D. M., Ripatti, S., Andreassen, O. A., Espeseth, T., Lundervold, A. J., Steen, V. M., Pinto, D., Scherer, S. W., Aschauer, H., Schosser, A., Alfredsson, L., Padyukov, L., Halmi, K. A., Mitchell, J., Strober, M., Bergen, A. W., Kaye, W., Szatkiewicz, J. P., Cormand, B., Ramos-Quiroga, J. A., Sanchez-Mora, C., Ribases, M., Casas, M., Hervas, A., Arranz, M. J., Haavik, J., Zayats, T., Johansson, S., Williams, N., Dempfle, A., Rothenberger, A., Kuntsi, J., Oades, R. D., Banaschewski, T., Franke, B., Buitelaar, J. K., Arias Vasquez, A., Doyle, A. E., Reif, A., Lesch, K.-P., Freitag, C., Rivero, O., Palmason, H., Romanos, M., Langley, K., Rietschel, M., Witt, S. H., Dalsgaard, S., Borglum, A. D., Waldman, I., Wilmot, B., Molly, N., Bau, C. H. D., Crosbie, J., Schachar, R., Loo, S. K., McGough, J. J., Grevet, E. H., Medland, S. E., Robinson, E., Weiss, L. A., Bacchelli, E., Bailey, A., Bal, V., Battaglia, A., Betancur, C., Bolton, P., Cantor, R., Celestino-Soper, P., Dawson, G., De Rubeis, S., Duque, F., Green, A., Klauck, S. M., Leboyer, M., Levitt, P., Maestrini, E., Mane, S., De-Luca, D. M.-, Parr, J., Regan, R., Reichenberg, A., Sandin, S., Vorstman, J., Wassink, T., Wijsman, E., Cook, E., Santangelo, S., Delorme, R., Roge, B., Magalhaes, T., Arking, D., Schulze, T. G., Thompson, R. C., Strohmaier, J., Matthews, K., Melle, I., Morris, D., Blackwood, D., McIntosh, A., Bergen, S. E., Schalling, M., Jamain, S., Maaser, A., Fischer, S. B., Reinbold, C. S., Fullerton, J. M., Guzman-Parra, J., Mayoral, F., Schofield, P. R., Cichon, S., Mühleisen, T. W., Degenhardt, F., Schumacher, J., Bauer, M., Mitchell, P. B., Gershon, E. S., Rice, J., Potash, J. B., Zandi, P. P., Craddock, N., Ferrier, I. N., Alda, M., Rouleau, G. A., Turecki, G., Ophoff, R., Pato, C., Anjorin, A., Stahl, E., Leber, M., Czerski, P. M., Cruceanu, C., Jones, I. R., Posthuma, D., Andlauer, T. F. M., Forstner, A. J., Streit, F., Baune, B. T., Air, T., Sinnamon, G., Wray, N. R., MacIntyre, D. J., Porteous, D., Homuth, G., Rivera, M., Grove, J., Middeldorp, C. M., Hickie, I., Pergadia, M., Mehta, D., Smit, J. H., Jansen, R., de Geus, E., Dunn, E., Li, Q. S., Nauck, M., Schoevers, R. A., Beekman, A. T., Knowles, J. A., Viktorin, A., Arnold, P., Barr, C. L., Bedoya-Berrio, G., Bienvenu, O. J., Brentani, H., Burton, C., Camarena, B., Cappi, C., Cath, D., Cavallini, M., Cusi, D., Darrow, S., Denys, D., Derks, E. M., Dietrich, A., Fernandez, T., Figee, M., Freimer, N., Gerber, G., Grados, M., Greenberg, E., Hanna, G. L., Hartmann, A., Hirschtritt, M. E., Hoekstra, P. J., Huang, A., Huyser, C., Illmann, C., Jenike, M., Kuperman, S., Leventhal, B., Lochner, C., Lyon, G. J., Macciardi, F., Madruga-Garrido, M., Malaty, I. A., Maras, A., McGrath, L., Miguel, E. C., Mir, P., Nestadt, G., Nicolini, H., Okun, M. S., Pakstis, A., Paschou, P., Piacentini, J., Pittenger, C., Plessen, K., Ramensky, V., Ramos, E. M., Reus, V., Richter, M. A., Riddle, M. A., Robertson, M. M., Roessner, V., Rosario, M., Samuels, J. F., Sandor, P., Stein, D. J., Tsetsos, F., Van Nieuwerburgh, F., Weatherall, S., Wendland, J. R., Wolanczyk, T., Worbe, Y., Zai, G., Goes, F. S., McLaughlin, N., Nestadt, P. S., Grabe, H.-J., Depienne, C., Konkashbaev, A., Lanzagorta, N., Valencia-Duarte, A., Bramon, E., Buccola, N., Cahn, W., Cairns, M., Chong, S. A., Cohen, D., Crespo-Facorro, B., Crowley, J., Davidson, M., DeLisi, L., Dinan, T., Donohoe, G., Drapeau, E., Duan, J., Haan, L., Hougaard, D., Karachanak-Yankova, S., Khrunin, A., Klovins, J., Kucinskas, V., Lee Chee Keong, J., Limborska, S., Loughland, C., Lönnqvist, J., Maher, B., Mattheisen, M., McDonald, C., Murphy, K. C., Nenadic, I., van Os, J., Pantelis, C., Pato, M., Petryshen, T., Quested, D., Roussos, P., Sanders, A. R., Schall, U., Schwab, S. G., Sim, K., So, H.-C., Stögmann, E., Subramaniam, M., Toncheva, D., Waddington, J., Walters, J., Weiser, M., Cheng, W., Cloninger, R., Curtis, D., Gejman, P. V., Henskens, F., Mattingsdal, M., Oh, S.-Y., Scott, R., Webb, B., Breen, G., Churchhouse, C., Bulik, C. M., Daly, M., Dichgans, M., Faraone, S. V., Guerreiro, R., Holmans, P., Kendler, K. S., Koeleman, B., Mathews, C. A., Price, A., Scharf, J., Sklar, P., Williams, J., Wood, N. W., Cotsapas, C., Palotie, A., Smoller, J. W., Sullivan, P., Rosand, J., Corvin, A., Neale, B. M.
  • News at a glance June 21, 2018
  • The human prefrontal cortex is special June 21, 2018
    Stern, P.
  • U.S. center will fight infections with viruses June 21, 2018
    Servick, K.
  • Disjointed no more June 21, 2018
    Czajka, C.
  • Reports of inner-ear damage deepen diplomat controversy June 21, 2018
    Stone, R.
  • New genus of extinct Holocene gibbon associated with humans in Imperial China June 21, 2018
    Although all extant apes are threatened with extinction, there is no evidence for human-caused extinctions of apes or other primates in postglacial continental ecosystems, despite intensive anthropogenic pressures associated with biodiversity loss for millennia in many regions. Here, we report a new, globally extinct genus and species of gibbon, Junzi imperi […]
    Turvey, S. T., Bruun, K., Ortiz, A., Hansford, J., Hu, S., Ding, Y., Zhang, T., Chatterjee, H. J.
  • Rising bedrock may delay ice sheet collapse June 21, 2018
    Langin, K.
  • Finding the vulnerable minority June 21, 2018
    Hurtley, S. M.
  • Neanderthal brain organoids come to life June 21, 2018
    Cohen, J.
  • Paired photoreceptors function as an oceanic depth gauge June 21, 2018
    Hines, P. J.
  • Radio arrays take shape in the global south June 21, 2018
    Clery, D.
  • Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates June 21, 2018
    It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarizatio […]
    Banerjee-Ghosh, K., Ben Dor, O., Tassinari, F., Capua, E., Yochelis, S., Capua, A., Yang, S.-H., Parkin, S. S. P., Sarkar, S., Kronik, L., Baczewski, L. T., Naaman, R., Paltiel, Y.
  • NIH kills alcohol trial, starts hunt for other suspect studies June 21, 2018
    Wadman, M.
  • New Products June 21, 2018
  • Chinese grave reveals vanished gibbon genus June 21, 2018
    Vogel, G.
  • Brainstorming diseases June 21, 2018
    Zahn, L. M.
  • Feeding the gods June 21, 2018
    Wade, L.
  • Taking enantiomers for a spin June 21, 2018
    Yeston, J.
  • Mechanisms behind the monarch's decline June 21, 2018
    Agrawal, A. A., Inamine, H.
  • Benzene ice clouds in Titan's atmosphere June 21, 2018
    Smith, K. T.
  • How did Homo sapiens evolve? June 21, 2018
    Galway-Witham, J., Stringer, C.
  • A good excuse to sleep in June 21, 2018
    Kelly, P. N.
  • Aberrant choice behavior in alcoholism June 21, 2018
    Spanagel, R.
  • A molecular mechanism for choosing alcohol over an alternative reward June 21, 2018
    Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which ~15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the -ami […]
    Augier, E., Barbier, E., Dulman, R. S., Licheri, V., Augier, G., Domi, E., Barchiesi, R., Farris, S., Nätt, D., Mayfield, R. D., Adermark, L., Heilig, M.
  • Receptor networks underpin plant immunity June 21, 2018
    Wu, C.-H., Derevnina, L., Kamoun, S.
  • Anomalously low dielectric constant of confined water June 21, 2018
    The dielectric constant of interfacial water has been predicted to be smaller than that of bulk water ( 80) because the rotational freedom of water dipoles is expected to decrease near surfaces, yet experimental evidence is lacking. We report local capacitance measurements for water confined between two atomically flat walls separated by various distances do […]
    Fumagalli, L., Esfandiar, A., Fabregas, R., Hu, S., Ares, P., Janardanan, A., Yang, Q., Radha, B., Taniguchi, T., Watanabe, K., Gomila, G., Novoselov, K. S., Geim, A. K.
  • Feel the dielectric force June 21, 2018
    Kalinin, S. V.
  • Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares June 21, 2018
    Snowshoe hares (Lepus americanus) maintain seasonal camouflage by molting to a white winter coat, but some hares remain brown during the winter in regions with low snow cover. We show that cis-regulatory variation controlling seasonal expression of the Agouti gene underlies this adaptive winter camouflage polymorphism. Genetic variation at Agouti clustered b […]
    Jones, M. R., Mills, L. S., Alves, P. C., Callahan, C. M., Alves, J. M., Lafferty, D. J. R., Jiggins, F. M., Jensen, J. D., Melo-Ferreira, J., Good, J. M.
  • Combating deforestation: From satellite to intervention June 21, 2018
    Finer, M., Novoa, S., Weisse, M. J., Petersen, R., Mascaro, J., Souto, T., Stearns, F., Martinez, R. G.
  • In vivo brain GPCR signaling elucidated by phosphoproteomics June 21, 2018
    A systems view of G protein–coupled receptor (GPCR) signaling in its native environment is central to the development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR) as a model, we employed high-throughput phosphoproteomics to investigate signaling induced by structurally diverse agonists in five mouse brain regions. Quant […]
    Liu, J. J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S. J., Chiu, Y.-T., Spetea, M., Liu-Chen, L.-Y., Schwarzer, C., Mann, M.
  • Hard feelings June 21, 2018
    Bauer, E.
  • Emerging stem cell ethics June 21, 2018
    Sipp, D., Munsie, M., Sugarman, J.
  • The Victorian dynamo June 21, 2018
    Dry, S.
  • Mechanisms of drug action June 21, 2018
    Ray, L. B.
  • Evaluating human trials: FDA's role June 21, 2018
    Krause, P. R., Gruber, M. F.
  • Time and place of electron exit June 21, 2018
    Yeston, J.
  • Response--Evaluating human trials: FDA's role June 21, 2018
    Shah, S. K., Kimmelman, J., Lyerly, A. D., Lynch, H. F., Miller, F. G., Palacios, R., Pardo, C. A., Zorrilla, C.
  • Water's surface dielectric June 21, 2018
    Szuromi, P.
  • Casualties of human-wildlife conflict June 21, 2018
    Grande, J. M., Zuluaga, S., Marchini, S.
  • Surface antibody maturation June 21, 2018
    Scanlon, S. T.
  • Hybrid camouflage variation June 21, 2018
    Vignieri, S.
  • Making a triple negative June 21, 2018
    Yeston, J.
  • China's plastic waste import ban June 21, 2018
    Benson, P. J.
  • A ray of hope for advanced breast cancer June 21, 2018
    Kiberstis, P. A.
  • The noblewoman's ape June 21, 2018
    Vignieri, S.
  • Warming in Greenland's past June 21, 2018
    Smith, H. J.
  • Dialing down the opioids June 21, 2018
    Ferrarelli, L. K.
  • Tunable quantum criticality and super-ballistic transport in a "charge" Kondo circuit June 21, 2018
    Quantum phase transitions (QPTs) are ubiquitous in strongly correlated materials. However, the microscopic complexity of these systems impedes the quantitative understanding of QPTs. We observed and thoroughly analyzed the rich strongly correlated physics in two profoundly dissimilar regimes of quantum criticality. With a circuit implementing a quantum simul […]
    Iftikhar, Z., Anthore, A., Mitchell, A. K., Parmentier, F. D., Gennser, U., Ouerghi, A., Cavanna, A., Mora, C., Simon, P., Pierre, F.
  • Fingers on the trigger June 21, 2018
    Williams, I.
  • Orientation-dependent stereo Wigner time delay and electron localization in a small molecule June 21, 2018
    Attosecond metrology of atoms has accessed the time scale of the most fundamental processes in quantum mechanics. Transferring the time-resolved photoelectric effect from atoms to molecules considerably increases experimental and theoretical challenges. Here we show that orientation- and energy-resolved measurements characterize the molecular stereo Wigner t […]
    Vos, J., Cattaneo, L., Patchkovskii, S., Zimmermann, T., Cirelli, C., Lucchini, M., Kheifets, A., Landsman, A. S., Keller, U.
  • A nanostructure quantum simulator June 21, 2018
    Stajic, J.
  • Observed rapid bedrock uplift in Amundsen Sea Embayment promotes ice-sheet stability June 21, 2018
    The marine portion of the West Antarctic Ice Sheet (WAIS) in the Amundsen Sea Embayment (ASE) accounts for one-fourth of the cryospheric contribution to global sea-level rise and is vulnerable to catastrophic collapse. The bedrock response to ice mass loss, glacial isostatic adjustment (GIA), was thought to occur on a time scale of 10,000 years. We used new […]
    Barletta, V. R., Bevis, M., Smith, B. E., Wilson, T., Brown, A., Bordoni, A., Willis, M., Khan, S. A., Rovira-Navarro, M., Dalziel, I., Smalley, R., Kendrick, E., Konfal, S., Caccamise, D. J., Aster, R. C., Nyblade, A., Wiens, D. A.
  • A quick rebound for Antarctic crust June 21, 2018
    Grocholski, B.
  • A precise extragalactic test of General Relativity June 21, 2018
    Einstein’s theory of gravity, General Relativity, has been precisely tested on Solar System scales, but the long-range nature of gravity is still poorly constrained. The nearby strong gravitational lens ESO 325-G004 provides a laboratory to probe the weak-field regime of gravity and measure the spatial curvature generated per unit mass, . By reconstructing t […]
    Collett, T. E., Oldham, L. J., Smith, R. J., Auger, M. W., Westfall, K. B., Bacon, D., Nichol, R. C., Masters, K. L., Koyama, K., van den Bosch, R.
  • Testing General Relativity on galaxy scales June 21, 2018
    Smith, K. T.
  • Locally coordinated synaptic plasticity of visual cortex neurons in vivo June 21, 2018
    Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neurons remains unknown. We found that spike timing–induced receptive field plasticity of visual cortex neurons in mice is anchored by increases in the synaptic s […]
    El-Boustani, S., Ip, J. P. K., Breton-Provencher, V., Knott, G. W., Okuno, H., Bito, H., Sur, M.
  • Rebalancing strength between synapses June 21, 2018
    Stern, P.
  • Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope June 21, 2018
    Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective antibodies against the circumsporozoite protein of the malaria pa […]
    Imkeller, K., Scally, S. W., Bosch, A., Marti, G. P., Costa, G., Triller, G., Murugan, R., Renna, V., Jumaa, H., Kremsner, P. G., Sim, B. K. L., Hoffman, S. L., Mordmüller, B., Levashina, E. A., Julien, J.-P., Wardemann, H.
  • Where have all the monarchs gone? June 21, 2018
    Fahrenkamp-Uppenbrink, J.
  • Dinner without reservations June 21, 2018
    Smith, M. L.
  • Out of Africa, with a difference June 21, 2018
    Fahrenkamp-Uppenbrink, J.
  • Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death" June 21, 2018
    Shlezinger et al. (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fun […]
    Aouacheria, A., Cunningham, K. W., Hardwick, J. M., Palkova, Z., Powers, T., Severin, F. F., Vachova, L.
  • Networks in plant immunity June 21, 2018
    Alderton, G.
  • Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death" June 21, 2018
    Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulation […]
    Shlezinger, N., Irmer, H., Dhingra, S., Beattie, S. R., Cramer, R. A., Braus, G. H., Sharon, A., Hohl, T. M.

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