Science Translational Medicine

  • [Editors' Choice] A molecular warning system for invasive pneumococcus June 20, 2018
    A genome-wide association study of Streptococcus pneumoniae identifies and validates bacterial loci associated with invasive infection.
    Langelier, C.
  • [Editors' Choice] Ketogenic bugs as epilepsy drugs June 20, 2018
    The gut microbiome mediates the beneficial effects of a ketogenic diet on epileptic seizures through modulation of GABA/glutamate ratios in the hippocampus.
    Nance, E. A.
  • [Research Articles] The ERBB network facilitates KRAS-driven lung tumorigenesis June 20, 2018
    KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling; however, recent data suggest that this independence may not be absolute. We show that in […]
    Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P., Murphy, D. J.
  • [Editors' Choice] Improving "gut feelings" for poorly water-soluble drugs June 20, 2018
    A nanocarrier system self-assembled in the intestine significantly improves oral availability of poorly water-soluble drugs.
    Shen, K.
  • [Research Articles] Afatinib restrains K-RAS-driven lung tumorigenesis June 20, 2018
    On the basis of clinical trials using first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), it became a doctrine that V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-RAS) mutations drive resistance to EGFR inhibition in non–small cell lung cancer (NSCLC). Conversely, we provide evidence that EGFR signaling is eng […]
    Moll, H. P., Pranz, K., Musteanu, M., Grabner, B., Hruschka, N., Mohrherr, J., Aigner, P., Stiedl, P., Brcic, L., Laszlo, V., Schramek, D., Moriggl, R., Eferl, R., Moldvay, J., Dezso, K., Lopez-Casas, P. P., Stoiber, D., Hidalgo, M., Penninger, J., Sibilia, M., Gyorffy, B., Barbacid, M., Dome, B., Popper, H., Casanova, E.
  • [Research Articles] Tissue engineering toward temporomandibular joint disc regeneration June 20, 2018
    Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with me […]
    Vapniarsky, N., Huwe, L. W., Arzi, B., Houghton, M. K., Wong, M. E., Wilson, J. W., Hatcher, D. C., Hu, J. C., Athanasiou, K. A.
  • [Research Articles] Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism June 20, 2018
    Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. To address this, we performed deep RNA sequencing of gluteal subcutaneous adipose tissue from 25 healthy humans […]
    Zhang, X., Xue, C., Lin, J., Ferguson, J. F., Weiner, A., Liu, W., Han, Y., Hinkle, C., Li, W., Jiang, H., Gosai, S., Hachet, M., Garcia, B. A., Gregory, B. D., Soccio, R. E., Hogenesch, J. B., Seale, P., Li, M., Reilly, M. P.

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